Saline sonogram vs hsg2/25/2023 Hysterosalpingography Polycystic ovary syndrome Saline infusion sonohysterography Saline ultrasound. SIS is an acceptable imaging modality for assessment of tubal patency in this population. In this large cohort of women with PCOS, there was no significant difference in clinical pregnancy rate between women who had tubal patency confirmed by HSG versus SIS. Ectopic pregnancy occurred more often in women who had tubal patency confirmed by HSG compared to SIS (2.8% versus 0.6%, P = 0.02). Multivariable analysis indicated that choice of HSG versus SIS did not have a significant relationship on likelihood of clinical pregnancy, after adjustment for treatment arm, BMI, duration of infertility, smoking, and education (OR 1.14, 95% CI 0.77, 1.67, P = 0.52). Logistic regression was conducted in patients who ovulated with clinical pregnancy as the outcome and HSG or SIS as the key independent variable.Īmong women who ovulated, 414 (66.9%) had tubal patency confirmed by SIS and 187 (30.2%) had at least one tube patent on HSG. Prior to enrollment, tubal patency was determined by HSG, the presence of free fluid in the pelvis on SIS, laparoscopy, or recent intrauterine pregnancy. Seven hundred fifty infertile women (18-40 years old) with polycystic ovary syndrome (PCOS) were randomized to up to 5 cycles of letrozole or clomiphene citrate. Secondary analysis of a randomized controlled trial, Pregnancy in Polycystic Ovary Syndrome II (PPCOS II). To compare saline infusion sonohysterography (SIS) versus hysterosalpingogram (HSG) for confirmation of tubal patency. 14 Department of Obstetrics and Gynecology, University of Colorado, Aurora, CO, USA.13 Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA.12 Department of Obstetrics and Gynecology, Women and Infants Hospital, Warren Alpert Medical School of Brown University, Providence, RI, USA.11 Department of Obstetrics and Gynecology, Shands Hospital, University of Florida, Gainesville, FL, USA.10 Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA, USA.9 Department of Obstetrics and Gynecology, University of Vermont, Burlington, VT, USA.8 Department of Obstetrics, Gynecologyn, and Reproductive Biology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.7 Department of Obstetrics and Gynecology, University of Rochester School of Medicine, Rochester, NY, USA.6 Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.5 Department of Obstetrics and Gynecology, Georgia Regents University, Augusta, GA, USA.4 Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.3 Department of Biostatistics, Yale University School of Public Health, New Haven, CT, USA.2 Department of Ob/Gyn, Penn State College of Medicine, Hershey, PA, USA. 1 Department of Gynecology and Obstetrics, Division of Reproductive Endocrinology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Saline Sonogram (SIS) Also known as a saline infusion sonogram or a sonohysterogram, a SIS is a transvaginal ultrasound test that is performed while a sterile saline solution is gently infused into the uterus.
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